Version 5.4
Homo sapiens Protein: MAGED4B
Summary
InnateDB Protein IDBP-476129.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGED4B
Protein Name melanoma antigen family D, 4B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000421861
InnateDB Gene IDBG-68383 (MAGED4B)
Protein Structure
UniProt Annotation
Function May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269PubMed:20864041}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples. {ECO:0000269PubMed:11406556, ECO:0000269PubMed:16082191}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Protein Structure and Domains
PDB ID
InterPro IPR002190 MAGE protein
PFAM PF01454
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JG8
PhosphoSite PhosphoSite-Q96JG8
TrEMBL
UniProt Splice Variant
Entrez Gene 81557
UniGene Hs.729070
RefSeq NP_001229291
HUGO HGNC:22880
OMIM 300765
CCDS CCDS56602
HPRD 06631
IMGT
EMBL AB040527 AB040528 AB040529 AB056059 AB058762 AF320908 AF329733 AK289458 AL136582 AL928717 BC001207 BC063838 BC081566 BX537154 CH471230
GenPept AAG38604 AAH01207 AAH63838 AAH81566 AAL50032 BAB33378 BAB33379 BAB33380 BAB47488 BAB61778 BAB61779 BAB61780 BAF82147 CAB66517 CAI40426 CAI41307 EAW62885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca