Homo sapiens Protein: FAS
InnateDB Protein IDBP-476300.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAS
Protein Name Fas (TNF receptor superfamily, member 6)
Synonyms ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6;
Species Homo sapiens
Ensembl Protein ENSP00000422453
InnateDB Gene IDBG-81669 (FAS)
Protein Structure
UniProt Annotation
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269PubMed:19118384, ECO:0000269PubMed:7533181}.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.Isoform 4: Secreted.Isoform 5: Secreted.Isoform 6: Secreted.
Disease Associations Autoimmune lymphoproliferative syndrome 1A (ALPS1A) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269PubMed:10090885, ECO:0000269PubMed:10340403, ECO:0000269PubMed:10515860, ECO:0000269PubMed:11418480, ECO:0000269PubMed:17336828, ECO:0000269PubMed:7540117, ECO:0000269PubMed:8929361, ECO:0000269PubMed:9028321, ECO:0000269PubMed:9028957, ECO:0000269PubMed:9322534, ECO:0000269PubMed:9821419, ECO:0000269PubMed:9927496}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. {ECO:0000269PubMed:7575433}.
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 109 [view]
Protein-DNA 10 [view]
Protein-RNA 3 [view]
DNA-DNA 1 [view]
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0071455 cellular response to hyperoxia
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
InterPro IPR001368 TNFR/NGFR cysteine-rich region
IPR008063 Fas receptor
PFAM PF00020
Post-translational Modifications
SwissProt P25445
PhosphoSite PhosphoSite-P25445
UniProt Splice Variant
Entrez Gene 355
UniGene Hs.623093
OMIM 134637
HPRD 00609
EMBL AK290978 AL157394 AY450925 AY495076 BC012479 CH471066 FM246458 M67454 X63717 X83490 X83491 X83492 X83493 X89101 Z47993 Z47994 Z47995 Z66556 Z70519 Z70520
GenPept AAA63174 AAH12479 AAR08906 AAS76663 BAF83667 CAA45250 CAA61473 CAA88031 CAA88032 CAA88033 CAA94430 CAA94431 CAI13870 CAI13871 CAI13872 CAR92543 EAW50151