InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX25

Summary

InnateDB Protein

IDBP-476436.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX25

Protein Name

sorting nexin 25

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000426255

InnateDB Gene

IDBG-46721 (SNX25)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. {ECO:0000250}.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:14975938}; Peripheral membrane protein {ECO:0000269PubMed:14975938}. Note=Detected in endosome-derived secreted vesicles (exosomes) from malignant pleural effusions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0034713	type I transforming growth factor beta receptor binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032801	receptor catabolic process
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation

Cellular Component

GO:0005575	cellular_component
GO:0005768	endosome
GO:0010008	endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000342 Regulator of G protein signalling domain
IPR001683 Phox homologous domain
IPR003114 Phox-associated domain
IPR013937 Sorting nexin, C-terminal
IPR013996 PX-associated, sorting nexin 13
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00787
PF02194
PF08628

PRINTS

PR01301

PIRSF

SMART

SM00312
SM00313
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt