InnateDB Protein
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IDBP-477137.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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THOC5
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Protein Name
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THO complex 5
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Synonyms
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C22orf19; Fmip; fSAP79; PK1.3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000420306
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InnateDB Gene
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IDBG-3643 (THOC5)
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Protein Structure
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Function |
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
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Subcellular Localization |
Nucleus. Nucleus speckle {ECO:0000305}. Cytoplasm {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019163
THO complex, subunit 5
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PFAM |
PF09766
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13769
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PhosphoSite |
PhosphoSite-Q13769
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TrEMBL |
C9JXU6
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UniProt Splice Variant |
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Entrez Gene |
8563
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UniGene |
Hs.75361
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RefSeq |
NP_003669
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HUGO |
HGNC:19074
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OMIM |
612733
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CCDS |
CCDS13859
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HPRD |
16650
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IMGT |
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EMBL |
AB023200
AC005529
AJ006069
BC003615
CH471095
CR456542
L18972
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GenPept |
AAC26837
AAH03615
BAA76827
CAA06841
CAG30428
EAW59808
EAW59811
EAW59812
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