InnateDB Protein
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IDBP-477219.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPIA
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Protein Name
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peptidylprolyl isomerase A (cyclophilin A)
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Synonyms
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CYPA; CYPH; HEL-S-69p;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000419425
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InnateDB Gene
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IDBG-15159 (PPIA)
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Protein Structure
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Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16527992}. Secreted {ECO:0000269PubMed:16527992}. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
83
[view]
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Protein-Protein |
79
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002130
Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR029000
Cyclophilin-like domain
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PFAM |
PF00160
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PRINTS |
PR00153
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P62937
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PhosphoSite |
PhosphoSite-P62937
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TrEMBL |
V9HWF5
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UniProt Splice Variant |
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Entrez Gene |
5478
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UniGene |
Hs.733874
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RefSeq |
NP_066953
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HUGO |
HGNC:9253
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OMIM |
123840
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CCDS |
CCDS5494
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HPRD |
17376
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IMGT |
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EMBL |
AB451307
AB451438
AC004854
AC013436
AK290085
AK293003
AY739283
BC000689
BC003026
BC005320
BC005982
BC007104
BC013915
BC073992
BC093076
BC106030
BC137057
BC137058
CR456707
EU794650
X52851
Y00052
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GenPept |
AAH00689
AAH03026
AAH05320
AAH05982
AAH07104
AAH13915
AAH73992
AAH93076
AAI06031
AAI37058
AAI37059
AAU13906
ACJ13704
BAF82774
BAF85692
BAG70121
BAG70252
CAA37039
CAA68264
CAG32988
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