Version 5.4
Homo sapiens Protein: NCEH1
Summary
InnateDB Protein IDBP-477394.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCEH1
Protein Name neutral cholesterol ester hydrolase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418571
InnateDB Gene IDBG-65183 (NCEH1)
Protein Structure
UniProt Annotation
Function Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. {ECO:0000269PubMed:17052608}.
Subcellular Localization Membrane {ECO:0000305PubMed:12149457}; Single-pass type II membrane protein {ECO:0000305PubMed:12149457}. Microsome {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines. {ECO:0000269PubMed:12149457, ECO:0000269PubMed:18782767}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013094 Alpha/beta hydrolase fold-3
IPR017157 Arylacetamide deacetylase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF07859
PRINTS
PIRSF PIRSF037251
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PIU2
PhosphoSite PhosphoSite-Q6PIU2
TrEMBL
UniProt Splice Variant
Entrez Gene 57552
UniGene Hs.595231
RefSeq
HUGO HGNC:29260
OMIM 613234
CCDS
HPRD 07489
IMGT
EMBL AB037784 AC007919 AC069237 AK294811 AK295641 AK299422 AK304253 AK316431 BC028734 BC047588
GenPept AAH28734 AAH47588 BAA92601 BAH11890 BAH12137 BAH13028 BAH14142 BAH14802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca