Version 5.4
Homo sapiens Protein: PARP14
Summary
InnateDB Protein IDBP-477436.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP14
Protein Name poly (ADP-ribose) polymerase family, member 14
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418194
InnateDB Gene IDBG-52688 (PARP14)
Protein Structure
UniProt Annotation
Function Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity. {ECO:0000250, ECO:0000269PubMed:16061477}.
Subcellular Localization Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002589 Macro domain
IPR004170 WWE domain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
PFAM PF01661
PF02825
PF00644
PRINTS
PIRSF
SMART SM00506
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q460N5
PhosphoSite PhosphoSite-Q460N5
TrEMBL
UniProt Splice Variant
Entrez Gene 54625
UniGene Hs.619286
RefSeq NP_060024
HUGO HGNC:29232
OMIM 610028
CCDS CCDS46894
HPRD 11421
IMGT
EMBL AB033094 AC048348 AC092908 AK001770 AK022542 AK304269 AY134858 DB237115 DQ063584 DQ063585
GenPept AAN08627 AAY64449 AAY64450 BAA86582 BAA91897 BAB14089 BAG65132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca