InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTNR1A

Summary

InnateDB Protein

IDBP-47754.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTNR1A

Protein Name

melatonin receptor 1A

Synonyms

MEL-1A-R; MT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000302811

InnateDB Gene

IDBG-47752 (MTNR1A)

Protein Structure

UniProt Annotation

Function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008502	melatonin receptor activity
GO:0042562	hormone binding
GO:0097159	organic cyclic compound binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007617	mating behavior
GO:0007623	circadian rhythm
GO:0030828	positive regulation of cGMP biosynthetic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000025 Melatonin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR002278 Melatonin receptor 1A
IPR002279 Melatonin receptor type 1C
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00857
PR00237
PR01012
PR01149
PR01150

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48039