InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IQGAP2

Summary

InnateDB Protein

IDBP-477859.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IQGAP2

Protein Name

IQ motif containing GTPase activating protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000426027

InnateDB Gene

IDBG-29509 (IQGAP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005095	GTPase inhibitor activity
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0043086	negative regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005874	microtubule
GO:0015629	actin cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000593 RasGAP protein, C-terminal
IPR001202 WW domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF03836
PF00397
PF00616

PRINTS

PIRSF

SMART

SM00015
SM00456
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13576