InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR7

Summary

InnateDB Protein

IDBP-47803.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR7

Protein Name

chemokine (C-C motif) receptor 7

Synonyms

BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1;

Species

Homo sapiens

Ensembl Protein

ENSP00000246657

InnateDB Gene

IDBG-47801 (CCR7)

Protein Structure

UniProt Annotation

Function

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0035757	chemokine (C-C motif) ligand 19 binding
GO:0035758	chemokine (C-C motif) ligand 21 binding
GO:0038117	C-C motif chemokine 19 receptor activity
GO:0038121	C-C motif chemokine 21 receptor activity

Biological Process

GO:0001768	establishment of T cell polarity
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002407	dendritic cell chemotaxis
GO:0002408	myeloid dendritic cell chemotaxis
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002885	positive regulation of hypersensitivity
GO:0002922	positive regulation of humoral immune response
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0030838	positive regulation of actin filament polymerization
GO:0031274	positive regulation of pseudopodium assembly
GO:0031529	ruffle organization
GO:0032496	response to lipopolysaccharide
GO:0032649	regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0032862	activation of Rho GTPase activity
GO:0034695	response to prostaglandin E
GO:0038115	chemokine (C-C motif) ligand 19 signaling pathway
GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045060	negative thymic T cell selection
GO:0045087	innate immune response (InnateDB)
GO:0045785	positive regulation of cell adhesion
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0050706	regulation of interleukin-1 beta secretion
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051491	positive regulation of filopodium assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0070098	chemokine-mediated signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071345	cellular response to cytokine stimulus
GO:0071731	response to nitric oxide
GO:0072610	interleukin-12 secretion
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0097022	lymphocyte migration into lymph node
GO:0097029	mature dendritic cell differentiation
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000147	positive regulation of cell motility
GO:2000510	positive regulation of dendritic cell chemotaxis
GO:2000522	positive regulation of immunological synapse formation
GO:2000525	positive regulation of T cell costimulation
GO:2000526	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO:2000547	regulation of dendritic cell dendrite assembly

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR001718 CC chemokine receptor 7
IPR005383 CC chemokine receptor like 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR00645
PR00641
PR01558

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32248