InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRCA1

Summary

InnateDB Protein

IDBP-478642.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRCA1

Protein Name

breast cancer 1, early onset

Synonyms

BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53;

Species

Homo sapiens

Ensembl Protein

ENSP00000418960

InnateDB Gene

IDBG-52172 (BRCA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 625 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	625 [view]
Protein-Protein	603 [view]
Protein-DNA	15 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006974	cellular response to DNA damage stimulus
GO:0007098	centrosome cycle
GO:0009048	dosage compensation by inactivation of X chromosome
GO:0016567	protein ubiquitination
GO:0035066	positive regulation of histone acetylation
GO:0035067	negative regulation of histone acetylation
GO:0043009	chordate embryonic development
GO:0044030	regulation of DNA methylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051572	negative regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0051574	positive regulation of histone H3-K9 methylation
GO:0070512	positive regulation of histone H4-K20 methylation
GO:2000617	positive regulation of histone H3-K9 acetylation
GO:2000620	positive regulation of histone H4-K16 acetylation

Cellular Component

GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001357 BRCT domain
IPR001841 Zinc finger, RING-type
IPR011364 Breast cancer type 1 susceptibility protein (BRCA1)
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00533
PF12738
PF13639
PF14634
PF00097

PRINTS

PR00493

PIRSF

PIRSF001734

SMART

SM00292
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References