InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLR3

Summary

InnateDB Protein

IDBP-478741.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLR3

Protein Name

toll-like receptor 3

Synonyms

CD283; IIAE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000423386

InnateDB Gene

IDBG-47294 (TLR3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	38 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0032722	positive regulation of chemokine production
GO:0034138	toll-like receptor 3 signaling pathway
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0051607	defense response to virus