Version 5.4
Homo sapiens Protein: ENY2
Summary
InnateDB Protein IDBP-479463.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENY2
Protein Name enhancer of yellow 2 homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000429986
InnateDB Gene IDBG-32588 (ENY2)
Protein Structure
UniProt Annotation
Function Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. {ECO:0000269PubMed:18206972, ECO:0000269PubMed:21746879}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000255HAMAP- Rule:MF_03046, ECO:0000269PubMed:22307388}. Nucleus, nuclear pore complex {ECO:0000255HAMAP-Rule:MF_03046, ECO:0000269PubMed:22307388}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006325 chromatin organization
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006406 mRNA export from nucleus
GO:0015031 protein transport
GO:0016578 histone deubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000124 SAGA complex
GO:0005643 nuclear pore
GO:0070390 transcription export complex 2
GO:0071819 DUBm complex
Protein Structure and Domains
PDB ID
InterPro IPR018783 Transcription factor, enhancer of yellow 2
PFAM PF10163
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPA8
PhosphoSite PhosphoSite-Q9NPA8
TrEMBL A0A024R9D9
UniProt Splice Variant
Entrez Gene 56943
UniGene Hs.639728
RefSeq NP_064574
HUGO HGNC:24449
OMIM
CCDS CCDS43762
HPRD 13121
IMGT
EMBL AC021237 AF173296 AF201940 AK290752 AK316560 BC007870 CH471060 CR457183
GenPept AAF86876 AAF89829 AAH07870 BAF83441 BAG38149 CAG33464 EAW91927 EAW91928 EAW91930

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca