InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LARP1

Summary

InnateDB Protein

IDBP-479693.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LARP1

Protein Name

La ribonucleoprotein domain family, member 1

Synonyms

LARP;

Species

Homo sapiens

Ensembl Protein

ENSP00000428589

InnateDB Gene

IDBG-54950 (LARP1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. {ECO:0000269PubMed:20430826, ECO:0000269PubMed:23711370, ECO:0000269PubMed:24532714}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20430826, ECO:0000269PubMed:24532714}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.

Experimentally validated
Total	68 [view]
Protein-Protein	68 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000339	RNA cap binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0008190	eukaryotic initiation factor 4E binding
GO:0008494	translation activator activity
GO:0031369	translation initiation factor binding
GO:0044822	poly(A) RNA binding
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006413	translational initiation
GO:0008283	cell proliferation
GO:0016239	positive regulation of macroautophagy
GO:0031929	TOR signaling
GO:0045727	positive regulation of translation