Version 5.4
Homo sapiens Protein: GIMAP4
Summary
InnateDB Protein IDBP-48014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIMAP4
Protein Name GTPase, IMAP family member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000255945
InnateDB Gene IDBG-48012 (GIMAP4)
Protein Structure
UniProt Annotation
Function May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:23454188}.
Disease Associations
Tissue Specificity Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine. {ECO:0000269PubMed:23454188}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR006703 AIG1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04548
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NUV9
PhosphoSite PhosphoSite-Q9NUV9
TrEMBL
UniProt Splice Variant
Entrez Gene 55303
UniGene Hs.647101
RefSeq NP_060796
HUGO HGNC:21872
OMIM 608087
CCDS CCDS5904
HPRD 16281
IMGT
EMBL AF117333 AK001972 BC020657
GenPept AAH20657 AAO15308 BAA92010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca