InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHAD

Summary

InnateDB Protein

IDBP-480246.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHAD

Protein Name

chondroadherin

Synonyms

SLRR4A;

Species

Homo sapiens

Ensembl Protein

ENSP00000423812

InnateDB Gene

IDBG-58589 (CHAD)

Protein Structure

UniProt Annotation

Function

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Present in chondrocytes at all ages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001502	cartilage condensation
GO:0060348	bone development
GO:1900155	negative regulation of bone trabecula formation

Cellular Component

GO:0005578

proteinaceous extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01462
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00013
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15335