InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KAT7

Summary

InnateDB Protein

IDBP-481033.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT7

Protein Name

K(lysine) acetyltransferase 7

Synonyms

HBO1; HBOA; MYST2; ZC2HC7;

Species

Homo sapiens

Ensembl Protein

ENSP00000423385

InnateDB Gene

IDBG-57826 (KAT7)

Protein Structure

UniProt Annotation

Function

Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. {ECO:0000269PubMed:10438470, ECO:0000269PubMed:10930412, ECO:0000269PubMed:11278932, ECO:0000269PubMed:16387653}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:10930412, ECO:0000269PubMed:11278932, ECO:0000269PubMed:16387653}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in testis. {ECO:0000269PubMed:10438470, ECO:0000269PubMed:10930412}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	65 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0006260	DNA replication
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043983	histone H4-K12 acetylation