InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPS6KA2

Summary

InnateDB Protein

IDBP-481069.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA2

Protein Name

ribosomal protein S6 kinase, 90kDa, polypeptide 2

Synonyms

HU-2; MAPKAPK1C; p90-RSK3; pp90RSK3; RSK; RSK3; S6K-alpha; S6K-alpha2;

Species

Homo sapiens

Ensembl Protein

ENSP00000427015

InnateDB Gene

IDBG-98954 (RPS6KA2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269PubMed:16878154, ECO:0000269PubMed:7623830}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:7623830}. Cytoplasm {ECO:0000269PubMed:7623830}.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. {ECO:0000269PubMed:16878154, ECO:0000269PubMed:7623830}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004711	ribosomal protein S6 kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0001556	oocyte maturation
GO:0002035	brain renin-angiotensin system
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010628	positive regulation of gene expression
GO:0010659	cardiac muscle cell apoptotic process
GO:0018105	peptidyl-serine phosphorylation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035556	intracellular signal transduction
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response
GO:0045786	negative regulation of cell cycle
GO:0045835	negative regulation of meiosis
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051403	stress-activated MAPK cascade
GO:0060047	heart contraction
GO:0070613	regulation of protein processing
GO:0071322	cellular response to carbohydrate stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293
PF00433

PRINTS

PR00109

PIRSF

PIRSF000606

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References