InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNAP91

Summary

InnateDB Protein

IDBP-481517.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAP91

Protein Name

synaptosomal-associated protein, 91kDa homolog (mouse)

Synonyms

AP180; CALM;

Species

Homo sapiens

Ensembl Protein

ENSP00000428215

InnateDB Gene

IDBG-93854 (SNAP91)

Protein Structure

UniProt Annotation

Function

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005545	1-phosphatidylinositol binding
GO:0019901	protein kinase binding
GO:0030276	clathrin binding