Version 5.4
Homo sapiens Protein: MAML3
Summary
InnateDB Protein IDBP-481749.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAML3
Protein Name mastermind-like 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000421180
InnateDB Gene IDBG-38637 (MAML3)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269PubMed:12370315, ECO:0000269PubMed:12386158}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:12370315}. Note=Nuclear, in a punctate manner.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
Biological Process
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007219 Notch signaling pathway
GO:0010467 gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR019082 Neurogenic mastermind-like, N-terminal
PFAM PF09596
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JK9
PhosphoSite PhosphoSite-Q96JK9
TrEMBL Q9NPV6
UniProt Splice Variant
Entrez Gene 55534
UniGene Hs.696744
RefSeq NP_061187
HUGO HGNC:16272
OMIM 608991
CCDS CCDS54805
HPRD 10066
IMGT
EMBL AB058719 AC097464 AC104798 AC108053 AC131182 AK123604 AL359614 BC137130 BC137131 CH471056
GenPept AAI37131 AAI37132 BAB47445 BAG53919 CAB94884 EAX05107

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca