InnateDB Protein
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IDBP-481749.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAML3
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Protein Name
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mastermind-like 3 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000421180
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InnateDB Gene
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IDBG-38637 (MAML3)
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Protein Structure
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Function |
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269PubMed:12370315, ECO:0000269PubMed:12386158}.
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Subcellular Localization |
Nucleus speckle {ECO:0000269PubMed:12370315}. Note=Nuclear, in a punctate manner.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003713
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transcription coactivator activity
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Biological Process |
GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0007219
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Notch signaling pathway
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GO:0010467
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gene expression
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR019082
Neurogenic mastermind-like, N-terminal
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PFAM |
PF09596
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JK9
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PhosphoSite |
PhosphoSite-Q96JK9
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TrEMBL |
Q9NPV6
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UniProt Splice Variant |
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Entrez Gene |
55534
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UniGene |
Hs.696744
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RefSeq |
NP_061187
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HUGO |
HGNC:16272
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OMIM |
608991
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CCDS |
CCDS54805
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HPRD |
10066
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IMGT |
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EMBL |
AB058719
AC097464
AC104798
AC108053
AC131182
AK123604
AL359614
BC137130
BC137131
CH471056
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GenPept |
AAI37131
AAI37132
BAB47445
BAG53919
CAB94884
EAX05107
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