Version 5.4
Homo sapiens Protein: NPM2
Summary
InnateDB Protein IDBP-482353.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPM2
Protein Name nucleophosmin/nucleoplasmin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000429413
InnateDB Gene IDBG-9959 (NPM2)
Protein Structure
UniProt Annotation
Function Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. {ECO:0000269PubMed:21863821}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0042393 histone binding
Biological Process
GO:0006338 chromatin remodeling
GO:0007096 regulation of exit from mitosis
GO:0007338 single fertilization
GO:0009790 embryo development
GO:0009994 oocyte differentiation
GO:0045836 positive regulation of meiosis
Cellular Component
GO:0000789 cytoplasmic chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR024057 Nucleoplasmin core domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86SE8
PhosphoSite PhosphoSite-Q86SE8
TrEMBL E5RGN1
UniProt Splice Variant
Entrez Gene 10361
UniGene
RefSeq
HUGO HGNC:7930
OMIM 608073
CCDS CCDS6018
HPRD 12160
IMGT
EMBL AC091171 AK094267 AY262113 AY262114 BC068078 CH471080
GenPept AAH68078 AAP33134 AAP33135 BAG52852 EAW63731 EAW63732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca