InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TTK

Summary

InnateDB Protein

IDBP-482582.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TTK

Protein Name

TTK protein kinase

Synonyms

CT96; ESK; MPH1; MPS1; MPS1L1; PYT;

Species

Homo sapiens

Ensembl Protein

ENSP00000422936

InnateDB Gene

IDBG-93500 (TTK)

Protein Structure

UniProt Annotation

Function

Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. {ECO:0000269PubMed:18243099}.

Subcellular Localization

Disease Associations

Tissue Specificity

Present in rapidly proliferating cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007051	spindle organization
GO:0007052	mitotic spindle organization
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0008284	positive regulation of cell proliferation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0051304	chromosome separation

Cellular Component

GO:0005819	spindle
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt