Version 5.4
Homo sapiens Protein: ERC2
Summary
InnateDB Protein IDBP-483156.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERC2
Protein Name ELKS/RAB6-interacting/CAST family member 2
Synonyms CAST; CAST1; ELKSL; SPBC110; Spc110;
Species Homo sapiens
Ensembl Protein ENSP00000417445
InnateDB Gene IDBG-40751 (ERC2)
Protein Structure
UniProt Annotation
Function Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12923177}. Cell junction, synapse {ECO:0000269PubMed:12923177}. Cell junction, synapse, synaptosome {ECO:0000269PubMed:12923177}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12923177}. Note=In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0030426 growth cone
GO:0042734 presynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR009053 Prefoldin
IPR019323 CAZ complex, RIM-binding protein
PFAM PF10174
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15083
PhosphoSite PhosphoSite-O15083
TrEMBL
UniProt Splice Variant
Entrez Gene 26059
UniGene Hs.693223
RefSeq XP_005265093
HUGO HGNC:31922
OMIM
CCDS CCDS46851
HPRD 10810
IMGT
EMBL AB002376 BC046212 BC111550 BC112391
GenPept AAI11551 AAI12392 BAA20832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca