InnateDB Protein
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IDBP-483162.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP6V1C1
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Protein Name
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ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
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Synonyms
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ATP6C; ATP6D; VATC; Vma5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000430282
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InnateDB Gene
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IDBG-31515 (ATP6V1C1)
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Protein Structure
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Function |
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:12384298}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005215
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transporter activity
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GO:0005515
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protein binding
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GO:0015078
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hydrogen ion transmembrane transporter activity
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GO:0046961
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proton-transporting ATPase activity, rotational mechanism
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004907
ATPase, V1 complex, subunit C
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PFAM |
PF03223
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P21283
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PhosphoSite |
PhosphoSite-P21283
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TrEMBL |
E7EV59
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UniProt Splice Variant |
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Entrez Gene |
528
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UniGene |
Hs.86905
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RefSeq |
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HUGO |
HGNC:856
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OMIM |
603097
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CCDS |
CCDS6296
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HPRD |
04371
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IMGT |
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EMBL |
AF363578
AP003550
BC010960
CH471060
J05682
X69151
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GenPept |
AAA36803
AAH10960
AAL50383
CAA48903
EAW91859
EAW91860
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