InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K6

Summary

InnateDB Protein

IDBP-483388.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K6

Protein Name

mitogen-activated protein kinase kinase kinase 6

Synonyms

ASK2; MAPKKK6; MEKK6;

Species

Homo sapiens

Ensembl Protein

ENSP00000419591

InnateDB Gene

IDBG-94865 (MAP3K6)

Protein Structure

UniProt Annotation

Function

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269PubMed:17210579, ECO:0000269PubMed:9875215}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007257	activation of JUN kinase activity

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013761 Sterile alpha motif/pointed domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt