Version 5.4
Homo sapiens Protein: CDC25B
Summary
InnateDB Protein IDBP-48361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC25B
Protein Name cell division cycle 25 homolog B (S. pombe)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000245960
InnateDB Gene IDBG-48355 (CDC25B)
Protein Structure
UniProt Annotation
Function Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. {ECO:0000269PubMed:17332740}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 50 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000087 mitotic M phase
GO:0000278 mitotic cell cycle
GO:0001556 oocyte maturation
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0007067 mitotic nuclear division
GO:0007144 female meiosis I
GO:0008284 positive regulation of cell proliferation
GO:0032467 positive regulation of cytokinesis
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045860 positive regulation of protein kinase activity
GO:0045931 positive regulation of mitotic cell cycle
Cellular Component
GO:0000922 spindle pole
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000751 M-phase inducer phosphatase
IPR001763 Rhodanese-like domain
PFAM PF06617
PF00581
PRINTS PR00716
PIRSF
SMART SM00450
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30305
PhosphoSite PhosphoSite-P30305
TrEMBL D3DVY6
UniProt Splice Variant
Entrez Gene 994
UniGene Hs.153752
RefSeq NP_068659
HUGO HGNC:1726
OMIM 116949
CCDS CCDS13067
HPRD 00307
IMGT
EMBL AF036233 AK092713 AL109804 AY494082 BC006395 BC009953 BC051711 CH471133 FR695900 M81934 S78187 X96436 Z68092
GenPept AAA58416 AAB21139 AAB94622 AAB94624 AAH06395 AAH09953 AAH51711 AAR26469 BAG52600 CAA65303 CAA92108 CAC17548 CAC17549 CAI18847 CBX26628 EAX10489 EAX10491 EAX10492 EAX10493 EAX10494 EAX10495 EAX10496 EAX10497 EAX10498 EAX10499 EAX10500 EAX10501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca