InnateDB Protein
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IDBP-484147.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAGED4B
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Protein Name
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melanoma antigen family D, 4B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000423848
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InnateDB Gene
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IDBG-68383 (MAGED4B)
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Protein Structure
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Function |
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269PubMed:20864041}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples. {ECO:0000269PubMed:11406556, ECO:0000269PubMed:16082191}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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PDB ID |
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InterPro |
IPR002190
MAGE protein
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PFAM |
PF01454
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JG8
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PhosphoSite |
PhosphoSite-Q96JG8
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TrEMBL |
A0A024R2A8
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UniProt Splice Variant |
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Entrez Gene |
81557
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UniGene |
Hs.729070
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RefSeq |
XP_005276770
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HUGO |
HGNC:22880
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OMIM |
300765
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CCDS |
CCDS14338
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HPRD |
06631
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IMGT |
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EMBL |
AB040527
AB040528
AB040529
AB056059
AB058762
AF320908
AF329733
AK289458
AL136582
AL928717
BC001207
BC063838
BC081566
BX537154
CH471230
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GenPept |
AAG38604
AAH01207
AAH63838
AAH81566
AAL50032
BAB33378
BAB33379
BAB33380
BAB47488
BAB61778
BAB61779
BAB61780
BAF82147
CAB66517
CAI40426
CAI41307
EAW62885
EAW62888
EAW62894
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