Version 5.4
Homo sapiens Protein: RAI14
Summary
InnateDB Protein IDBP-484428.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAI14
Protein Name retinoic acid induced 14
Synonyms NORPEG; RAI13;
Species Homo sapiens
Ensembl Protein ENSP00000422942
InnateDB Gene IDBG-15251 (RAI14)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269PubMed:11042181, ECO:0000269PubMed:16729964}. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (By similarity). Predominantly nuclear in nonconfluent cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa. {ECO:0000269PubMed:11042181, ECO:0000269PubMed:11168586, ECO:0000269PubMed:16110356}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR009060 UBA-like
IPR010989 t-SNARE
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P0K7
PhosphoSite PhosphoSite-Q9P0K7
TrEMBL D6RF74
UniProt Splice Variant
Entrez Gene 26064
UniGene Hs.610855
RefSeq NP_001138993
HUGO HGNC:14873
OMIM 606586
CCDS CCDS34142
HPRD 09416
IMGT
EMBL AB037755 AC016602 AC025754 AC026801 AF155135 AK023135 AK314379 AL050011 AY317139 AY354204 BC052988
GenPept AAF44722 AAH52988 AAP84319 AAQ63889 BAA92572 BAG51161 CAB43236

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca