InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BACE1

Summary

InnateDB Protein

IDBP-484806.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BACE1

Protein Name

beta-site APP-cleaving enzyme 1

Synonyms

ASP2; BACE; HSPC104;

Species

Homo sapiens

Ensembl Protein

ENSP00000422461

InnateDB Gene

IDBG-73181 (BACE1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	31 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0008798	beta-aspartyl-peptidase activity
GO:0019899	enzyme binding

Biological Process

GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0050435	beta-amyloid metabolic process

Cellular Component

GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001461 Aspartic peptidase
IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
IPR021109 Aspartic peptidase domain

PFAM

PF00026

PRINTS

PR00792
PR01815
PR01816

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56817