Version 5.4
Homo sapiens Protein: KCNN2
Summary
InnateDB Protein IDBP-484864.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNN2
Protein Name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms hSK2; KCa2.2; SK2; SKCa 2; SKCA2;
Species Homo sapiens
Ensembl Protein ENSP00000427120
InnateDB Gene IDBG-37535 (KCNN2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005516 calmodulin binding
GO:0015269 calcium-activated potassium channel activity
GO:0016286 small conductance calcium-activated potassium channel activity
GO:0042803 protein homodimerization activity
GO:0051393 alpha-actinin binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0071805 potassium ion transmembrane transport
GO:1901379 regulation of potassium ion transmembrane transport
Cellular Component
GO:0005790 smooth endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
Protein Structure and Domains
PDB ID
InterPro IPR004178 Calmodulin-binding domain
IPR013099 Two pore domain potassium channel domain
IPR015449 Potassium channel, calcium-activated, SK
PFAM PF02888
PF07885
PF03530
PRINTS PR01451
PIRSF
SMART SM01053
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2S1
PhosphoSite PhosphoSite-Q9H2S1
TrEMBL
UniProt Splice Variant
Entrez Gene 3781
UniGene Hs.98280
RefSeq XP_006714676
HUGO HGNC:6291
OMIM 605879
CCDS CCDS4114
HPRD 09323
IMGT
EMBL AC025761 AC109482 AF239613 AF397175 AK289948 AY258141 BC015371 BC117454 BC117456 CH471086
GenPept AAG16728 AAH15371 AAI17455 AAI17457 AAK84039 AAP45946 BAF82637 EAW48975 EAW48976

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca