InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHX2

Summary

InnateDB Protein

IDBP-484939.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHX2

Protein Name

epoxide hydrolase 2, cytoplasmic

Synonyms

CEH; SEH;

Species

Homo sapiens

Ensembl Protein

ENSP00000430269

InnateDB Gene

IDBG-14092 (EPHX2)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. {ECO:0000269PubMed:12574508, ECO:0000269PubMed:12574510}.

Subcellular Localization

Cytoplasm. Peroxisome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004301	epoxide hydrolase activity
GO:0005102	receptor binding
GO:0015643	toxic substance binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0033885	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO:0042577	lipid phosphatase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0008152	metabolic process
GO:0008217	regulation of blood pressure
GO:0009636	response to toxic substance
GO:0010628	positive regulation of gene expression
GO:0016311	dephosphorylation
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0042632	cholesterol homeostasis
GO:0044281	small molecule metabolic process
GO:0045909	positive regulation of vasodilation
GO:0046272	stilbene catabolic process
GO:0046839	phospholipid dephosphorylation
GO:0072593	reactive oxygen species metabolic process
GO:0090181	regulation of cholesterol metabolic process

Cellular Component

GO:0005777	peroxisome
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000639 Epoxide hydrolase-like
IPR006439 HAD hydrolase, subfamily IA
IPR011945 Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal
IPR023214 HAD-like domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF00702
PF08282
PF13419

PRINTS

PR00111
PR00412
PR00413

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34913