InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPS6KA2

Summary

InnateDB Protein

IDBP-485302.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA2

Protein Name

ribosomal protein S6 kinase, 90kDa, polypeptide 2

Synonyms

HU-2; MAPKAPK1C; p90-RSK3; pp90RSK3; RSK; RSK3; S6K-alpha; S6K-alpha2;

Species

Homo sapiens

Ensembl Protein

ENSP00000422435

InnateDB Gene

IDBG-98954 (RPS6KA2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005840	ribosome
GO:0016020	membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293
PF00433

PRINTS

PR00109

PIRSF

PIRSF000606

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References