InnateDB Protein
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IDBP-48560.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANKHD1
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Protein Name
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ankyrin repeat and KH domain containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000297183
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InnateDB Gene
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IDBG-48558 (ANKHD1)
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Protein Structure
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Function |
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269PubMed:16098192}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16098192, ECO:0000269PubMed:16956752}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain. {ECO:0000269PubMed:14557257, ECO:0000269PubMed:16098192, ECO:0000269PubMed:16956752}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004087
K Homology domain
IPR004088
K Homology domain, type 1
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PFAM |
PF00013
PF13014
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PRINTS |
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PIRSF |
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SMART |
SM00322
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IWZ3
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PhosphoSite |
PhosphoSite-Q8IWZ3
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TrEMBL |
F6WFL0
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UniProt Splice Variant |
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Entrez Gene |
54882
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UniGene |
Hs.714342
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RefSeq |
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HUGO |
HGNC:24714
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OMIM |
610500
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CCDS |
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HPRD |
16489
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IMGT |
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EMBL |
AB029008
AC008438
AC011399
AF217646
AF258557
AF521882
AF521883
AK000904
AK022041
BC004457
BC009420
BC009909
BC117677
BC117678
BC127127
BC150486
CH471062
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GenPept |
AAG23760
AAG41779
AAH04457
AAH09420
AAH09909
AAI17678
AAI17679
AAI27128
AAI50487
AAO14943
AAO14944
BAA83037
BAA91417
BAB13958
EAW62055
EAW62058
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