InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NET1

Summary

InnateDB Protein

IDBP-48900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NET1

Protein Name

neuroepithelial cell transforming 1

Synonyms

ARHGEF8; NET1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000347134

InnateDB Gene

IDBG-48898 (NET1)

Protein Structure

UniProt Annotation

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269PubMed:21373644}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:8649828}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017049	GTP-Rho binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051451	myoblast migration
GO:0070301	cellular response to hydrogen peroxide
GO:0071479	cellular response to ionizing radiation
GO:0097190	apoptotic signaling pathway
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading