Version 5.4
Homo sapiens Protein: KIAA1524
Summary
InnateDB Protein IDBP-48969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIAA1524
Protein Name KIAA1524
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295746
InnateDB Gene IDBG-48967 (KIAA1524)
Protein Structure
UniProt Annotation
Function Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation. {ECO:0000269PubMed:17632056}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:12118381}. Note=Slightly concentrates in the perinuclear region.
Disease Associations
Tissue Specificity Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). {ECO:0000269PubMed:12118381, ECO:0000269PubMed:17632056}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007283 spermatogenesis
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TCG1
PhosphoSite PhosphoSite-Q8TCG1
TrEMBL
UniProt Splice Variant
Entrez Gene 57650
UniGene Hs.591308
RefSeq NP_065941
HUGO HGNC:29302
OMIM 610643
CCDS CCDS33812
HPRD 11151
IMGT
EMBL AB040957 AF334474 AK022912 AL713689 BC017659 BC063433 BC130564 BC136371
GenPept AAH17659 AAH63433 AAI30565 AAI36372 AAL11632 BAA96048 BAB14305 CAD28489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca