Version 5.4
Homo sapiens Protein: KRT9
Summary
InnateDB Protein IDBP-49413.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT9
Protein Name keratin 9
Synonyms CK-9; EPPK; K9;
Species Homo sapiens
Ensembl Protein ENSP00000246662
InnateDB Gene IDBG-49411 (KRT9)
Protein Structure
UniProt Annotation
Function May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly. {ECO:0000269PubMed:10218578, ECO:0000269PubMed:7507869}.
Subcellular Localization
Disease Associations Keratoderma, palmoplantar, epidermolytic (EPPK) [MIM:144200]: A dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins. Some patients may present knuckle pads, thick pads of skin appearing over the proximal phalangeal joints. {ECO:0000269PubMed:10632938, ECO:0000269PubMed:10844507, ECO:0000269PubMed:12072061, ECO:0000269PubMed:12192490, ECO:0000269PubMed:12838553, ECO:0000269PubMed:12926810, ECO:0000269PubMed:14675368, ECO:0000269PubMed:15099359, ECO:0000269PubMed:15115518, ECO:0000269PubMed:15605275, ECO:0000269PubMed:16911293, ECO:0000269PubMed:16961539, ECO:0000269PubMed:7511021, ECO:0000269PubMed:7512862, ECO:0000269PubMed:7516304, ECO:0000269PubMed:7523529, ECO:0000269PubMed:7532199, ECO:0000269PubMed:8647270, ECO:0000269PubMed:9204965, ECO:0000269PubMed:9856842}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in the terminally differentiated epidermis of palms and soles. {ECO:0000269PubMed:7507869}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
Biological Process
GO:0007283 spermatogenesis
GO:0008544 epidermis development
GO:0043588 skin development
GO:0045109 intermediate filament organization
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
PFAM PF00038
PRINTS PR01248
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35527
PhosphoSite PhosphoSite-P35527
TrEMBL K7EQQ3
UniProt Splice Variant
Entrez Gene 3857
UniGene Hs.654569
RefSeq NP_000217
HUGO HGNC:6447
OMIM 607606
CCDS CCDS32654
HPRD 06351
IMGT
EMBL AB001594 AC019349 BC121170 S69510 X75015 Z29074
GenPept AAC60619 AAI21171 BAA19418 CAA52924 CAA82315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca