InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMOX

Summary

InnateDB Protein

IDBP-49531.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMOX

Protein Name

spermine oxidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344595

InnateDB Gene

IDBG-49525 (SMOX)

Protein Structure

UniProt Annotation

Function

Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.

Subcellular Localization

Isoform 1: Cytoplasm. Nucleus.Isoform 4: Cytoplasm. Nucleus.Isoform 6: Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO:0000269PubMed:18422650}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0046592	polyamine oxidase activity
GO:0052894	norspermine:oxygen oxidoreductase activity
GO:0052895	N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity

Biological Process

GO:0006595	polyamine metabolic process
GO:0006596	polyamine biosynthetic process
GO:0006598	polyamine catabolic process
GO:0006805	xenobiotic metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046208	spermine catabolic process
GO:0055114	oxidation-reduction process