Version 5.4
Homo sapiens Protein: CD5
Summary
InnateDB Protein IDBP-49732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD5
Protein Name CD5 molecule
Synonyms LEU1; T1;
Species Homo sapiens
Ensembl Protein ENSP00000342681
InnateDB Gene IDBG-49730 (CD5)
Protein Structure
UniProt Annotation
Function May act as a receptor in regulating T-cell proliferation.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0008037 cell recognition
GO:0008283 cell proliferation
GO:0031295 T cell costimulation
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001190 SRCR domain
IPR003566 T-cell surface glycoprotein CD5
IPR017448 SRCR-like domain
PFAM PF00530
PRINTS PR00258
PR01409
PIRSF
SMART SM00202
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06127
PhosphoSite PhosphoSite-P06127
TrEMBL H6D9U9
UniProt Splice Variant
Entrez Gene 921
UniGene Hs.622502
RefSeq NP_055022
HUGO HGNC:1685
OMIM 153340
CCDS CCDS8000
HPRD 01078
IMGT
EMBL AJ237927 AJ237928 AJ237929 AJ237930 AJ237931 AJ237932 AK292698 AP000437 BC027901 EF064752 JN159748 X04391 X89405
GenPept AAH27901 ABK41935 AEZ67700 BAF85387 CAA27979 CAA61584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca