Version 5.4
Homo sapiens Protein: TYRP1
Summary
InnateDB Protein IDBP-49770.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYRP1
Protein Name tyrosinase-related protein 1
Synonyms b-PROTEIN; CAS2; CATB; GP75; OCA3; TRP; TRP1; TYRP;
Species Homo sapiens
Ensembl Protein ENSP00000370528
InnateDB Gene IDBG-49760 (TYRP1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0008152 metabolic process
GO:0042438 melanin biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0033162 melanosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR002227 Tyrosinase copper-binding domain
IPR008922 Uncharacterised domain, di-copper centre
PFAM PF00264
PRINTS PR00092
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E7EQI3
UniProt Splice Variant
Entrez Gene 7306
UniGene Hs.270279
RefSeq
HUGO HGNC:12450
OMIM 115501
CCDS
HPRD 00283
IMGT
EMBL AL138753
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca