InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K15

Summary

InnateDB Protein

IDBP-49868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K15

Protein Name

mitogen-activated protein kinase kinase kinase 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000345629

InnateDB Gene

IDBG-49866 (MAP3K15)

Protein Structure

UniProt Annotation

Function

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. {ECO:0000269PubMed:20362554}.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen. {ECO:0000269PubMed:20362554}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013761 Sterile alpha motif/pointed domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt