InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNDP2

Summary

InnateDB Protein

IDBP-5010.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNDP2

Protein Name

CNDP dipeptidase 2 (metallopeptidase M20 family)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325756

InnateDB Gene

IDBG-5004 (CNDP2)

Protein Structure

UniProt Annotation

Function

Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. {ECO:0000269PubMed:17121880, ECO:0000269PubMed:19346245}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12473676, ECO:0000269PubMed:17121880}.

Disease Associations

Tissue Specificity

Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. {ECO:0000269PubMed:12473676, ECO:0000269PubMed:17121880}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0008237	metallopeptidase activity
GO:0016787	hydrolase activity
GO:0016805	dipeptidase activity
GO:0034701	tripeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:1901687	glutathione derivative biosynthetic process