InnateDB Protein
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IDBP-50295.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C11orf9
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Protein Name
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chromosome 11 open reading frame 9
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Synonyms
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C11orf9; MRF; Ndt80; pqn-47;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278836
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InnateDB Gene
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IDBG-50293 (C11orf9)
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Protein Structure
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Function |
Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). {ECO:0000269PubMed:23966832}.Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. {ECO:0000269PubMed:23966832}.Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832). {ECO:0000269PubMed:23966832}.
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Subcellular Localization |
Myelin regulatory factor: Endoplasmic reticulum membrane; Single-pass membrane protein.Myelin regulatory factor, N-terminal: Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage.Myelin regulatory factor, C-terminal: Endoplasmic reticulum membrane; Single-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina. {ECO:0000269PubMed:10828591}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008967
p53-like transcription factor, DNA-binding
IPR024061
NDT80 DNA-binding domain
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PFAM |
PF05224
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2G1
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PhosphoSite |
PhosphoSite-Q9Y2G1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
745
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UniGene |
Hs.682698
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RefSeq |
NP_001120864
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HUGO |
HGNC:1181
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OMIM |
608329
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CCDS |
CCDS44622
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HPRD |
12213
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IMGT |
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EMBL |
AB023171
AF038536
AF086762
CH471076
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GenPept |
AAB92668
AAF28400
BAA76798
EAW73968
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