InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C11orf9

Summary

InnateDB Protein

IDBP-50297.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C11orf9

Protein Name

chromosome 11 open reading frame 9

Synonyms

C11orf9; MRF; Ndt80; pqn-47;

Species

Homo sapiens

Ensembl Protein

ENSP00000265460

InnateDB Gene

IDBG-50293 (C11orf9)

Protein Structure

UniProt Annotation

Function

Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). {ECO:0000269PubMed:23966832}.Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. {ECO:0000269PubMed:23966832}.Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832). {ECO:0000269PubMed:23966832}.

Subcellular Localization

Myelin regulatory factor: Endoplasmic reticulum membrane; Single-pass membrane protein.Myelin regulatory factor, N-terminal: Nucleus. Cytoplasm. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage.Myelin regulatory factor, C-terminal: Endoplasmic reticulum membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina. {ECO:0000269PubMed:10828591}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008233	peptidase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0014003	oligodendrocyte development
GO:0022010	central nervous system myelination
GO:0031643	positive regulation of myelination
GO:0032286	central nervous system myelin maintenance
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048709	oligodendrocyte differentiation