InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC23A2

Summary

InnateDB Protein

IDBP-50312.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC23A2

Protein Name

solute carrier family 23 (nucleobase transporters), member 2

Synonyms

NBTL1; SLC23A1; SVCT2; YSPL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000368637

InnateDB Gene

IDBG-50310 (SLC23A2)

Protein Structure

UniProt Annotation

Function

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19379732}; Multi-pass membrane protein {ECO:0000269PubMed:19379732}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008520	L-ascorbate:sodium symporter activity
GO:0008523	sodium-dependent multivitamin transmembrane transporter activity
GO:0015205	nucleobase transmembrane transporter activity
GO:0015229	L-ascorbic acid transporter activity
GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0006814	sodium ion transport
GO:0006979	response to oxidative stress
GO:0015851	nucleobase transport
GO:0015882	L-ascorbic acid transport
GO:0015993	molecular hydrogen transport
GO:0019852	L-ascorbic acid metabolic process
GO:0035461	vitamin transmembrane transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0070904	transepithelial L-ascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane