Version 5.4
Homo sapiens Protein: SPICE1
Summary
InnateDB Protein IDBP-50324.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPICE1
Protein Name spindle and centriole associated protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295872
InnateDB Gene IDBG-50322 (SPICE1)
Protein Structure
UniProt Annotation
Function Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269PubMed:20736305}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:20736305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:20736305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0046599 regulation of centriole replication
GO:0051310 metaphase plate congression
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N0Z3
PhosphoSite PhosphoSite-Q8N0Z3
TrEMBL C9J5T2
UniProt Splice Variant
Entrez Gene 152185
UniGene Hs.477144
RefSeq NP_653319
HUGO HGNC:25083
OMIM 613447
CCDS CCDS2973
HPRD 11242
IMGT
EMBL AC112128 AL832148 AY099107 BC019232 BC036951 CH471052
GenPept AAH19232 AAH36951 AAM34495 CAD91167 EAW79634 EAW79636 EAW79637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca