InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EN2

Summary

InnateDB Protein

IDBP-50346.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EN2

Protein Name

engrailed homeobox 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297375

InnateDB Gene

IDBG-50344 (EN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus.

Disease Associations

Note=Genetic variations in EN2 may be associated with susceptibility to autism.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0007275	multicellular organismal development
GO:0030182	neuron differentiation
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048666	neuron development

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000747 Homeodomain engrailed
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR019549 Homeobox engrailed, C-terminal
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF10525

PRINTS

PR00026
PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt