InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFIB

Summary

InnateDB Protein

IDBP-50414.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFIB

Protein Name

nuclear factor I/B

Synonyms

CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB2; NFIB3;

Species

Homo sapiens

Ensembl Protein

ENSP00000370340

InnateDB Gene

IDBG-50410 (NFIB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002062	chondrocyte differentiation
GO:0006260	DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010001	glial cell differentiation
GO:0021740	principal sensory nucleus of trigeminal nerve development
GO:0021960	anterior commissure morphogenesis
GO:0030324	lung development
GO:0030900	forebrain development
GO:0030902	hindbrain development
GO:0043392	negative regulation of DNA binding
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060486	Clara cell differentiation
GO:0060509	Type I pneumocyte differentiation
GO:0060510	Type II pneumocyte differentiation
GO:0061141	lung ciliated cell differentiation
GO:0071679	commissural neuron axon guidance
GO:2000791	negative regulation of mesenchymal cell proliferation involved in lung development
GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0044300	cerebellar mossy fiber

Protein Structure and Domains

PDB ID

InterPro

IPR000647 CTF transcription factor/nuclear factor 1
IPR003619 MAD homology 1, Dwarfin-type
IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain

PFAM

PF00859
PF03165
PF10524

PRINTS

PIRSF

SMART

SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00712