InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL2RA

Summary

InnateDB Protein

IDBP-50568.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL2RA

Protein Name

interleukin 2 receptor, alpha

Synonyms

CD25; IDDM10; IL2R; p55; TCGFR;

Species

Homo sapiens

Ensembl Protein

ENSP00000369293

InnateDB Gene

IDBG-50566 (IL2RA)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-2.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:17676041}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	12 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004911	interleukin-2 receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0019976	interleukin-2 binding

Biological Process

GO:0002437	inflammatory response to antigenic stimulus
GO:0006915	apoptotic process
GO:0006924	activation-induced cell death of T cells
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008283	cell proliferation
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0043029	T cell homeostasis
GO:0045582	positive regulation of T cell differentiation
GO:0046013	regulation of T cell homeostatic proliferation
GO:0050672	negative regulation of lymphocyte proliferation
GO:0050687	negative regulation of defense response to virus
GO:0050728	negative regulation of inflammatory response
GO:0050777	negative regulation of immune response