Homo sapiens Protein: POC1B
Summary
InnateDB Protein IDBP-50583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POC1B
Protein Name POC1 centriolar protein homolog B (Chlamydomonas)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323302
InnateDB Gene IDBG-50581 (POC1B)
Protein Structure
UniProt Annotation
Function Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. {ECO:0000269PubMed:19109428, ECO:0000269PubMed:20008567, ECO:0000269PubMed:23015594}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008283 cell proliferation
GO:0042384 cilium assembly
Cellular Component
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005814 centriole
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR013979 Translation initiation factor, beta propellor-like domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PF08662
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TC44
PhosphoSite PhosphoSite-Q8TC44
TrEMBL Q8IU52
UniProt Splice Variant
Entrez Gene 282809
UniGene Hs.604487
RefSeq NP_758440
HUGO HGNC:30836
OMIM 614784
CCDS CCDS31869
HPRD 18301
IMGT
EMBL AB053266 AB053276 AC010201 AC025034 AK074772 BC026080 CH471054 EF011619
GenPept AAH26080 ABK41109 BAB69057 BAB69430 BAC11198 EAW97425 EAW97426 EAW97427