InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DIAPH1

Summary

InnateDB Protein

IDBP-50635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIAPH1

Protein Name

diaphanous homolog 1 (Drosophila)

Synonyms

DFNA1; DIA1; DRF1; hDIA1; LFHL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000373709

InnateDB Gene

IDBG-50631 (DIAPH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007605	sensory perception of sound
GO:0008360	regulation of cell shape
GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization
GO:0032886	regulation of microtubule-based process
GO:0035372	protein localization to microtubule
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0071420	cellular response to histamine

Cellular Component

GO:0005737	cytoplasm
GO:0032587	ruffle membrane
GO:0072686	mitotic spindle

Protein Structure and Domains

PDB ID

InterPro

IPR009408 Formin Homology 1
IPR010465 DRF autoregulatory
IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR010978 tRNA-binding arm
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold

PFAM

PF06346
PF06345
PF06367
PF06371
PF02181

PRINTS

PIRSF

SMART

SM00498

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60610